Hepatitis B toolkit
Further information on the investigation and management of patients with hepatitis B virus (HBV) infection is located here. For ease of use, information is divided into topics with resources within each topic ordered by geographic application and categorised as worldwide, regional or country-specific. Please click on the links below for access to a range of links and services.
Although Gilead makes every effort to ensure the links provided are accurate, up-to-date and relevant, we cannot take responsibility for pages maintained by external providers. Gilead does not routinely screen, approve, review or endorse the contents of or use of any of the products or services that may be offered by these external sites.
Prevention
Worldwide
World Health Organization
Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection, 2015
The World Hepatitis Alliance
The World Hepatitis Alliance’s 2018-2020 Strategic Plan – Finding the Missing Millions – lobal campaign with the objective to raise awareness, influence national testing policies and encourage people to get screened and/ or become advocates in the journey to find the undiagnosed.
Regional
American Association for the Study of Liver Diseases (AASLD)
Update on Prevention, Diagnosis, and Treatment of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance
European Centre for Disease Prevention and Control
Hepatitis B and C epidemiology in selected population groups in the EU/EEA 2018
Public health guidance in brief on HIV, hepatitis B and C testing in the EU/EEA 2018
Guidance in brief: Prevention and control of blood-borne viruses in prison settings 2018
Hepatitis B and C testing activities, needs, and priorities in the EU/EEA 2017
France
French National Agency for Accreditation and Evaluation in Health
Consensus meeting – vaccines against HBV virus – recommendations
French Institute for Public Health Surveillance
Hepatitis B and C: supervision and prevention
Ministries of Social Affairs and Health
Support to people infected by HBV and HCV virus
Germany
National Institute of Health
Hepatitis B quality standards: priority areas for quality improvement in health and social care
Robert Koch Institute
Brief guide to public health on HIV, hepatitis B and C in the EU / EEA 2018
World Health Organization
Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection, 2017
Italy
HepC Onlus association
Chronic hepatitis B: WHO guidelines for diagnosis, therapy and prevention
Ministry of Health – Hepatitis B and C working group
Piano nazionale per la prevenzione delle epatiti virali da virus B e C (PNEV)/ National plan for viral hepatitis B and C prevention
Regional Health Agency – Tuscany
How to prevent, treat and cure a person with chronic Hepatitis B: new WHO guidance
Spain
Catalan Hepatic Diseases Association
Prevention of HBV transmission
Elsevier – Integral Medicine Journal
Chronic hepatitis B – epidemiology, transmission and prevention
Viral hepatitis epidemiology and prevention
UK
National Institute for Health and Care Excellence (NICE)
Hepatitis B Quality Standards: priority areas for quality improvement in health and social care
Screening and diagnosis
Worldwide
World Health Organization
Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection, 2015
Regional
American Association for the Study of Liver Diseases (AASLD)
Update on Prevention, Diagnosis, and Treatment of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance
European Association for Study of the Liver (EASL)
EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection, 2017
France
French National Agency for Accreditation and Evaluation in Health
Hepatitis B screening
Fact sheet Place of Point-of-Care Tests (POCTs) in hepatitis B screening strategy
Hepatitis B and C diagnosing algorithms
Viral hepatitis B and C biological screening strategies
Ministries of Social Affairs and Health
Management of people infected with hepatitis B or C
Germany
European Aids Clinical Society
Guidelines of the European AIDS Clinical Society for the Treatment of Hepatitis B Infections, 2017
European Association for the Study of the Liver
Update on Prevention, Diagnosis and Treatment of Chronic Hepatitis B: AASLD 2017 Hepatitis B Guide
German AIDS help
Baseline Assessment Tool
Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection, 2017
German liver help
Hepatitis B and C tests: people at risk of infection, 2017
Robert Koch Institute (RKI)
Hepatitis B and C testing: people at risk of infection, 2017
Italy
Italian Association for the study of the liver
HBV infection treatment: Address document of the italian association for the study of the liver
Italian Diagnostic Centre
Hepatitis B virus, serological markers
Lab Tests online – an Italian version from AACC Better Health through laboratory medicine
Lab Tests online – a corner of confidence – Hepatitis B
Spain
Catalan Hepatic Diseases Association
Hepatitis B diagnosis: how to know if you’re infected. Hepatitis B tests. Screening.
WHO guide to HBV and HCV screening
Gastroenterology World Organization
World Organization of Gastroenterology global guide – Hepatitis B (includes HBV diagnosis and monitoring; treatment; vaccination against HBV)
Lab Tests online – a spanish version from AACC Better Health through laboratory medicine
Lab Tests online – a corner of confidence – Hepatitis B
UK
National Institute for Health and Care Excellence (NICE)
Hepatitis B and C testing: people at risk of infection, 2013
Lab Tests online – a corner of confidence – Hepatitis B
Baseline assessment tool, 2012
Treatment guidelines
Worldwide
World Health Organization
Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection, 2015
American Association for the Study of Liver Diseases (AASLD)
Update on Prevention, Diagnosis, and Treatment of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance
European Association for Study of the Liver (EASL)
EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection, 2017
Regional
European Centre for Disease Prevention and Control
Public health guidance on HIV, hepatitis B and C testing in the EU/EEA, 2018
France
French National Agency for Accreditation and Evaluation in Health
Acts and benefits for long term condition – Chronic hepatitis B
Guide: Long term condition – Chronic Hepatitis B
Ministries of Social Affairs and Health
Management of people infected with hepatitis B or C
Germany
European Association for the Study of the Liver
Prophylaxis, diagnosis and treatment of hepatitis B virus infection – The German guideline
European Commission
Policies for sexually transmitted infections
National Healthcare Germany
Hepatitis B: guidance, data and analysis, 2018
German guidelines for the management of viral hepatitis
Robert Koch Institute
German guidelines for the screening, prevention and initial treatment of hepatitis B infections in the field of sexual health
Hepatitis B and D (chronic): diagnosis and management, 2017
Public Health Guidelines on HIV, Hepatitis B and D in the EU / EEA, 2018
World Health Organization
Guidelines for the prevention, care and treatment of persons with chronic hepatitis B and C infection, 2015
Italy
Italian Association for the study of the liver
HBV infection treatment: Address document of the italian association for the study of the liver
Practical indications for a shared management model between general practioner and hepatologist of the patient with chronic hepatitis B and hepatitis C virus.
Regional Health Agency – Tuscany
How to prevent, treat and cure a person with chronic Hepatitis B: new WHO guidance
Spain
EASL – European Association for the Study of the Liver
EASL 2017 clinical practice new guidelines
Ministry of Health, Social Politics and Equality
Primary Care – a guide to good clinical practice in Chronic hepatitis B
UK
British Association for Sexual Health and HIV
2017 interim update of the 2015 BASHH National Guidelines for the Management of the Viral Hepatitides
National Institute for Health and Care Excellence (NICE)
Hepatitis B (chronic): diagnosis and management, 2017
Public Health England
Hepatitis B: guidance, data and analysis, 2018
Information for patients with HBV
Regional
ELPA (European Liver Patients’ Association)
The Association was formed in 2004 by the amalgamation of 13 patient groups from 10 European and Mediterranean Basin countries
France
French National Agency for Accreditation and Evaluation in Health
Guide: Long term condition – Management of your disease, chronic hepatitis B – to live with a chronique hepatitis B
Hepatitis and Co-infections – forum
Hepatitis and Co-infections – forum
Ministries of Social Affairs and Health
Management of people infected with hepatitis B or C
SOS Hepatitis Federation: Hepatitis and Liver diseases
To live with a hepatitis
Germany
German liver and hepatitis support groups
Support group for liver diseases patients and their loved ones
Is your liver healthy?
German publications that can be downloaded for free
Online Counsel for Hepatitis B General
Patient information on hepatitis B
Public Health Deutschland
Protect your baby from hepatitis B
Robert Koch Institute
Information for patients with HBV, including hepatitis B tests and vaccinations
Italy
HepC Onlus association
EpaC – the portal to patients with hepatitis and liver disease – Epatite B
Italian Ministry of Health
Hepatitis B – Ministry of Health
Viral hepatitis – Hepatitis B (EPICENTRO: the public health epidemiology portal)
Information about hepatitis B epidemiology
Spain
Catalan Hepatic Diseases Association
Information about Hepatitis B
Live with hepatitis B – selfcare and quality of life
Natural evolution of HBV virus infection
The hepatitis B is positive, what now?
National Institute of Diabetes and Digestive and Kidney Diseases
Health information – hepatitis B
UK
British Liver Trust
The British Liver Trust provides a range of publications that can be downloaded for free.
Key publications have also been translated for several different nationalities:
Helpline: 0800 652 7330
UK Liver and Hepatitis Support Groups
Hepatitis B Foundation
A nonprofit organisation dedicated to finding a cure and improving the quality of life for those affected by hepatitis B worldwide.
– Fact sheets
– Online support groups
– Video library
Hepatitis B Positive Trust
Information for patients with HBV, including a national helpline in the UK.
Hepatitis B testing and vaccinations.
Hepatitis Scotland
Easily accessible information for those exposed to, or affected by, hepatitis B
NHS
General patient information on hepatitis B
Public Health England
Protecting your baby against hepatitis B leaflet
Resources for healthcare professionals
Worldwide
Regional
European Association for the Study of the Liver (EASL)
iLiver app is EASL’s own reviewed bedside resource that provides up to date clinical recommendations and information in more than 26 different areas of liver disease.
HEPscreen
Screening for hepatitis B and C among migrants in the European Union
World Health Organization, Europe
Information on hepatitis in the WHO European region
France
Ministries of Social Affairs and Health
Management of people infected with hepatitis B or C
Germany
Apps for liver diagnostics
The charisma app provides information on health, diagnosis and therapies
The iLiver app is an EASL-reviewed bedside resource that provides up-to-date clinical recommendations and information on more than 26 different liver diseases.
Note: The Hep iChart (Liverpool Drug Interactions Group) app can be downloaded from iTunes or the Google Play Store.
Deutsche Liver Foundation
Interactions with HEP drugs
Factsheets and reports
Hepatitis B fact sheet
Public Health Deutschland
Fibro Scan enables non-invasive liver diagnosis and treatment for patients with hepatitis B and C
Green book for a healthy future – aims to ensure a sustainable development of European healthcare in the long term
Health care professionals
Robert Koch Institute
Global Hepatitis Report 2017
World Health Organization, Europe
Information on hepatitis in the WHO European Region
Italy
Italian Ministry of Health
National plan for viral hepatitis B and C prevention
Regional Health Agency – Tuscany
How to prevent, treat and cure a person with chronic Hepatitis B: new WHO guidance
Viral hepatitis – Hepatitis B (EPICENTRO: the public health epidemiology portal)
Viral hepatitis – epidemiology
Spain
EASL – European Association for the Study of the Liver
EASL clinical practice new guidelines
Ministry of Health, Social Politics and Equality
Primary Care – Good clinical practice in chronic hepatitis B
Spanish association for the study of the liver
AEEH (Spanish association for the study of the liver) Consensus document on the treatment of HBV virus infection (2012)
Clinical practice guidelines (Spanish association for the study of the liver)
Hepatology white book Spain
UK
British Liver Trust
Love your liver national awareness campaign
Public Health England
The Green Book
University of Liverpool
HEP Drug Interactions
Note: The Hep iChart (Liverpool Drug Interactions Group) app can be downloaded via iTunes or Google Play Store.
Calculators and screening tools
International
AUDIT Alcohol Consumption Questions (AUDIT-C)
AST to Platelet Ratio Index (APRI) Calculator
CAGE Questionnaire for Detecting Alcoholism
Child-Pugh Score for Cirrhosis Mortality
Creatinine Clearance (CrCl) Calculator
Fibrosis-4 (FIB-4) Calculator
MELD Score (Model for End-Stage Liver Disease)
France
Body Mass Index (BMI)
Child Pugh Score
Cirrhosis scale
Fibrosis-4 (FIB-4) Score
Glasgow or Osborne Score
MELD (Model for End Stage Liver Disease) Score
NAFLD Score
Score APRI
Germany
AST to Platelet Ratio Index (APRI) Calculator
AUDIT Alcohol Consumption Questions (AUDIT-C)
BMI Healthy Weight Calculator (NHS)
CAGE Questionnaire for Detecting Alcoholism
Child-Pugh Score for Cirrhosis Mortality
Creatinine Clearance (CrCl) Calculator
eGFR Calculator (The Renal Association)
Fibrosis-4 (FIB-4) Calculator
MELD Score (Model for End-Stage Liver Disease)
Italy
Audit alcohol questions
APRI Calculator
BMI Calculator
CAGE Questionnaire for detecting alcoholism
Creatinine Clearance
eGFR calculator
Fibrosis-4 (FIB-4) Calculator
MELD Score (Model for End-Stage Liver Disease)
Spain
Are you an active person?
AST to Platelet Ratio Index (APRI) Calculator
AUDIT Alcohol Consumption Questions (AUDIT-C)
Autoimmune hepatitis score calculator
BMI Calculator
Child-Pugh Score
Fatty Liver Index Calculator
Fibrosis-4 (FIB-4) calculator
Glasgow alcoholic hepatitis score
Insulin resistance índex calculator
Know your consumption
Maddrey score calculator
Model for End Stage Liver Disease Score
NAFLD calculator
NAFLD Calculators (includes APRI índex, NAFLD fibrosis score, Fibrosis 4 score, Relación AST/ALT)
Viral Hepatitis Risk Asessment
UK
Continuing medical education
Regional
Clinical Care Options
Medical education materials, conference coverage and opinion pieces dealing with the management of viral hepatitis
European Association for the Study of the Liver (EASL)
The EASL LIVERTREETM
EASL members have access to the LiverTree, an online medical educational resource designed by hepatologists for hepatologists.
LiverLearning®
LiverLearning® is the official eLearning portal of AASLD. Users can access educational resources by categories, content type, and events – including videos and slide decks.
European Centre for Disease Prevention and Control
Training on infection control in the EU/EEA
France
Ministries of Social Affairs and Health
Management of people infected with hepatitis B or C
Germany
Clinical care options
Medical training materials, conference reports and opinion papers dealing with the management of viral hepatitis
European Center for Disease Prevention and Control
Anti-infection training in the EU / EEA
Learning to live in Berlin
Life Learning Berlin gives users access to educational resources by category, content type, and event – including videos and slide decks
Medical training
European Association for the Study of the Liver (EASL)
The EASL LIVERTREETM
EASL members have access to the LiverTree, an online educational resource for medical purposes developed by hepatologists for hepatologists.
Online advice on substance abuse and health
Online advice on substance abuse and associated health
Spain
Ministry of Health, Social Politics and Equality
Primairy Care – Good clinical practice in chronic hepatitis B
Spanish association for the study of the liver
Hepatology White Book Spain
Italy
Italian association for the study of the liver
National scientific association for the study of the liver
Italian foundation for hepatology research
UK
Royal College of General Practitioners (RCGP)
RCGP Substance Misuse and Associated Health (SMAH) alcohol certificate course.
National and international policies
Worldwide
World Health Organization
Combating hepatitis B and C to reach elimination by 2030
The time to cure hepatitis B is now – Promoting global collaboration in HBV cure research
Regional
ACHIEVE (Associations Collaborating on Hepatitis to Immunize and Eliminate the Viruses in Europe)
A collaboration of organisations including: the European Liver Patients’ Association (ELPS); EASL International Liver Foundation, World Hepatitis Alliance; Hepatitis B and C Policy Association; European Aids Treatment Group (EATG); Correlation Network; Viral Hepatitis Prevention Board and ISGlobal, University of Barcelona.
Hepatitis B & C Public Policy Association
A not-for-profit association responsible for the annual hepatitis B and C summit conference in Europe
France
French National Agency for Accreditation and Evaluation in Health
To improve the screening for viral hepatitis B and C
Germany
Health Germany
Acute Hepatitis B (Germany): Annual Report 2017
Hepatitis B & C Association
A non-profit association hepatitis B and C in Germany
Institute for Advanced Studies
Cooperation in hepatitis to immunize and eliminate viruses in Europe
Ministry of Health
Combating hepatitis B and C by the year 2030
Robert Koch Institute
Hepatitis B and C: Local surveillance standards
Italy
Italian Ministry of Health
National plan for viral hepatitis B and C prevention
Regional Health Agency – Tuscany
How to prevent, treat and cure a person with chronic Hepatitis B: new WHO guidance
Spain
Alliance for the elimination of viral hepatitis in Spain
Information about Hepatitis B
World Health Association
Global strategy of the Health sector against viral hepatitis 2016-2021 – towards the end of viral hepatitis
UK
Surveillance standards for the follow up of hepatitis B and C by local health protection teams
Hepatitis B and C: local surveillance standards
Public Health England
Acute hepatitis B (England): annual report for 2017
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LID/IHQ/18-12//1048C DATE OF PREPARATION: MARCH 2019